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  • Frontline Plus for dogs
  • Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment
  • Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment
  • Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment
  • Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment
  • Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment
  • Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment
  • Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment
Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment

Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment

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$34.89 $49.99
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Heavy-duty protection for small dogs

Big protection in a small package. Frontline Plus for Small Dogs (Orange Box) is the spot-on treatment built for dogs and puppies weighing 5–22 lbs — killing fleas, flea eggs, flea larvae, ticks and chewing lice with a single monthly application.

Kills fleas, ticks & chewing lice Waterproof after 24 hours One dose lasts 30 days

For dogs & puppies 8 weeks and older, weighing 5–22 lbs.

Frontline Plus for small dogs — flea and tick spot-on treatment Frontline Plus breaks the flea life cycle Frontline Plus waterproof protection for dogs Frontline Plus monthly application for small dogs

About this item

  • Breaks the flea life cycle — kills adult fleas, flea eggs and flea larvae, so an infestation can't rebuild itself
  • Fast-acting — a manufacturer study showed 100% of fleas killed within 12 hours1
  • Kills all tick life stages — brown dog, American dog, lone star and deer ticks, including ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis and anaplasmosis
  • Kills chewing lice and aids in the control of sarcoptic mange
  • Waterproof — once dry, bathing, swimming and rain won't wash it off
  • Safe for puppies from 8 weeks old, and for breeding, pregnant and nursing dogs
  • No prescription needed — one easy application per month

Why choose Frontline Plus for your dog

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Complete flea control

Adults die fast, and the growth regulator stops eggs and larvae ever reaching adulthood — in your dog's coat and around your home.

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Tick & lice defence

Covers all four major tick species at every life stage, plus chewing lice — protecting your family as well as your dog.

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Waterproof formula

Stored in the skin's oil glands and released steadily for 30 days. Let it dry 24 hours, then swim away.

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Gentle on puppies

Approved from 8 weeks and 5 lbs, and safe for breeding, pregnant or nursing dogs.

6

Six months of protection in one box

Six applicators, one per month — half a year of uninterrupted flea and tick cover without a repeat order.

How it works

Applied to one spot, the treatment spreads across your dog's entire skin surface through their natural oils and is stored in the sebaceous glands. Those glands act as a reservoir, topping the coat up continuously — which is why one dose keeps working for a full month, wet or dry.

Fipronil — disrupts the nervous system of fleas, ticks and chewing lice 9.8%
(S)-methoprene — insect growth regulator; stops eggs and larvae developing 8.8%
How Frontline Plus works on a dog's skin and coat

How to apply

  1. Remove the applicator. Use scissors to separate one blister, cut along the dotted line, then peel back the foil.
  2. Open it. Hold upright with the foil side facing you and snap the tip — away from your face and body.
  3. Find the spot. Part your dog's hair between the shoulder blades until you can see skin — one spot they can't turn around and lick.
  4. Apply. Place the tip just above the skin and squeeze out the entire contents in a single spot. Onto skin, not on top of the coat.
  5. Let it dry. Avoid touching the treated area. Wait a full 24 hours before bathing or swimming.
  6. Repeat every 30 days for continuous, year-round protection.

Specifications

Brand Frontline (Boehringer Ingelheim)
Form Topical liquid (spot-on)
Size Small dog, 5–22 lbs — Orange box
Count 6 applicators — 6-month supply
For Dogs & puppies, 8 weeks+, 5 lbs+
Duration 30 days per application
Actives Fipronil 9.8%, (S)-methoprene 8.8%
EPA Reg. No. 65331-5

⚠️ Important safety information

  • Keep cats away from treated dogs for 24 hours, or until the product has dried. If this product is applied to a cat or swallowed by a cat, contact your veterinarian immediately — dog formulations can be dangerous to cats.
  • Match the box to the weight. This orange box is for dogs 5–22 lbs only. Do not use on dogs under 5 lbs or puppies under 8 weeks.
  • Do not use more than one application per dog per month. Give each dog its own complete dose.
  • Individual sensitivities are rare but possible. Temporary irritation at the application site can occur; if it persists or worsens, contact your vet.
  • Harmful if swallowed. Causes eye irritation. Avoid contact with skin, eyes and clothing, and wash hands thoroughly after handling.
  • Children should not apply this product. Keep out of reach of children and pets.
  • For external use only. Read the entire label and enclosed directions before every use.

Why customers love this

No more sleepless, itchy nights

Pet parents report the scratching settles within a day or two of the first application — fast relief that holds for the full 30 days, without pills, collars or weekly baths.

A comfortable, itch-free dog resting

Frequently asked questions

How fast does it start working?

Fipronil begins killing on contact. A manufacturer study showed 100% of fleas killed within 12 hours of application.1 You may see fleas rise to the top of the coat as they die — that's the product working, not a new infestation.

When can my dog swim or have a bath?

Wait a full 24 hours after applying. Your dog should also be dry at the time of application. After that it's waterproof for the rest of the 30 days.

I have cats too — is that a problem?

Keep cats away from the treated dog for 24 hours or until the spot is completely dry. Never apply a dog product to a cat. If a cat is exposed or licks the treated area, call your vet straight away.

My dog is 24 lbs — can I use this box?

No. This box is for 5–22 lbs. Dogs 23–44 lbs need the medium (blue) box, 45–88 lbs the large (purple), and 89–132 lbs the extra-large (red). Never split or combine doses.

Is it safe for a pregnant or nursing dog?

Yes — Frontline Plus is approved for breeding, pregnant and lactating dogs, and for puppies from 8 weeks old.

I missed a month. What should I do?

Apply as soon as you remember, then wait a full 30 days before the next dose. Setting a phone reminder on application day is the easiest way to stay on schedule.

Protect your pup with Pawly Supply

Don't let fleas take over your home — secure your 6-month supply today and get back outdoors with confidence.

1 Data on file at Boehringer Ingelheim. "#1 name in flea and tick protection" and "trusted for over 20 years" are manufacturer claims supported by data held by Boehringer Ingelheim. This is an EPA-registered pesticide product; it is a violation of federal law to use it in a manner inconsistent with its labeling. Always read the product label before use and consult your veterinarian with any health concerns about your dog.

Enriching the lives of pets with elegant, quality products that reflect your love. Questions? Email support@pawlysupply.com or call +1 (667) 215-2885 — we're always happy to help.

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Customer Reviews

Overall rating: 4.6 / 5 from 2198 reviews.

Customer photo review of Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment

Our adventurous girl is ready to take on the world without having to worry about those pesky fleas!

Dakota J. 5/5 Verified

Frontline Plus for Small Dogs 5 to 22 lbs – 6 Month Flea and Tick Treatment

Store owner replied: Thank you so much for sharing this — we love hearing that your adventurous girl is fully protected and ready to take on the world!

Customer photo review of Frontline Plus for Small Dogs 5-22 lbs – 6 Month Flea & Tick Treatment

My little girl stays home and only goes out to go potty. She’s an older girl and she does well with Frontline. She’s had Frontline for flea and tick control ever since I rescued her almost 4 years ago. I used it on all of my other dogs and I will trust it for my future pets as well. I think the price is appropriate for 3 months of medication.

Catherine G. 5/5

Frontline Plus for Small Dogs 5-22 lbs – 6 Month Flea & Tick Treatment